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New phthalideisoquinoline hemiacetal alkaloid derivatives from Corydalis decumbens.
- Source :
-
Fitoterapia [Fitoterapia] 2020 Jul; Vol. 144, pp. 104494. Date of Electronic Publication: 2020 Feb 08. - Publication Year :
- 2020
-
Abstract
- Two new phthalideisoquinoline hemiacetal alkaloid derivatives, named corybensines A and B (1 and 2), and four known alkaloids (3-6) were isolated from the bulbs of Corydalis decumbens. Their structures were characterized by analysis of 1D/2D NMR and ECD data, quantum chemical ECD calculations, and X-ray diffraction analysis. Among them, compound 2 represents the first naturally occurring phthalideisoquinoline hemiacetal alkaloid derivative with a 2-pyrrolidinone moiety. The activity of the isolated compounds towards neuronal excitability was examined.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.<br /> (Copyright © 2020. Published by Elsevier B.V.)
- Subjects :
- Alkaloids isolation & purification
Animals
Calcium metabolism
Cells, Cultured
China
Isoquinolines isolation & purification
Mice, Inbred C57BL
Molecular Structure
Phytochemicals chemistry
Phytochemicals isolation & purification
Plant Roots chemistry
Alkaloids chemistry
Corydalis chemistry
Isoquinolines chemistry
Neurons drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 144
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 32045693
- Full Text :
- https://doi.org/10.1016/j.fitote.2020.104494