Management of children and adolescents with gray zone lymphoma: A case series.

Authors :: Perwein T
Lackner H
Ebetsberger-Dachs G
Beham-Schmid C
Zach K
Tamesberger M
Simonitsch-Klupp I
Lüftinger R
Dworzak M
Mann G
Benesch M
Attarbaschi A
Source :: Pediatric blood & cancer [Pediatr Blood Cancer] 2020 May; Vol. 67 (5), pp. e28206. Date of Electronic Publication: 2020 Feb 09.
Publication Year :: 2020
Abstract: Background: Data on management of gray zone lymphoma (GZL) in children and adolescents are scarce.<br />Procedure: This retrospective study assessed clinical characteristics and outcome in six Austrian patients with GZL less than 18 years of age (male-to-female ratio: 1:1; median age: 15.8 years).<br />Results: Two patients each had a classical Hodgkin lymphoma (cHL)-like and composite GZL subtype, and one patient each had a large B-cell non-Hodgkin lymphoma (LBCL)-like and sequential GZL subtype. All had advanced disease with mediastinal and extranodal involvement. Five patients received an LBCL- and one patient a cHL-directed polychemotherapy ± radiotherapy. Out of the former patients, three survived, including two who relapsed and underwent high-dose chemotherapy with autologous stem cell rescue. The latter patient survived.<br />Conclusions: GZL remains a diagnostic and therapeutic challenge, necessitating the development of novel treatment concepts performed in a prospective setting.<br /> (© 2020 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals, Inc.)