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Agenesis of the septum pellucidum: Prenatal diagnosis and outcome.
- Source :
-
Prenatal diagnosis [Prenat Diagn] 2020 May; Vol. 40 (6), pp. 674-680. Date of Electronic Publication: 2020 Mar 31. - Publication Year :
- 2020
-
Abstract
- Objective: The purpose of this study is to describe the imaging findings in a group of fetuses with suspected agenesis of the septum pellucidum (ASP) and to evaluate their clinical outcome.<br />Methods: This is a retrospective multicenter study on a cohort of fetuses diagnosed with suspected ASP, between 2008 and 2017. The records of each patient, including ultrasound (US) and magnetic resonance studies, were reviewed and compared with the postnatal findings.<br />Results: Forty-seven patients were included in the study at a mean gestational age of 26.6 weeks. In 17 patients, the ASP was considered isolated. Fourteen patients delivered live-born, and all 14 are developing normally. Three were lost to follow-up. Twenty-four patients had associated malformations involving the central nervous system (CNS); 13 were delivered (normal development [5], abnormal [6] and no follow-up [2]). Nine patients opted for termination, and two pregnancies were lost to follow-up. Six patients had non-CNS associated findings, two were delivered with normal neurological development and four had a termination.<br />Conclusions: Isolated ASP is usually associated with a favorable outcome; but in the presence of associated malformations, there is at least a 50% risk of abnormal development. Current imaging techniques can provide an accurate prognosis in cases when ASP appears isolated.<br /> (© 2020 John Wiley & Sons, Ltd.)
- Subjects :
- Abortion, Induced
Adolescent
Adult
Agenesis of Corpus Callosum diagnostic imaging
Cerebellum abnormalities
Cerebellum diagnostic imaging
Cohort Studies
Developmental Disabilities diagnostic imaging
Female
Gestational Age
Holoprosencephaly diagnostic imaging
Humans
Hydrocephalus diagnostic imaging
Infant, Newborn
Magnetic Resonance Imaging
Male
Nervous System Malformations physiopathology
Neurodevelopmental Disorders
Polymicrogyria diagnostic imaging
Pregnancy
Prognosis
Retrospective Studies
Schizencephaly diagnostic imaging
Septo-Optic Dysplasia physiopathology
Septum Pellucidum diagnostic imaging
Ultrasonography, Prenatal
Young Adult
Nervous System Malformations diagnostic imaging
Septo-Optic Dysplasia diagnostic imaging
Septum Pellucidum abnormalities
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0223
- Volume :
- 40
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Prenatal diagnosis
- Publication Type :
- Academic Journal
- Accession number :
- 32037567
- Full Text :
- https://doi.org/10.1002/pd.5663