[Diagnosis of Multiple System Atrophy for Establishing Disease-modifying Therapies].

More accurate and early diagnoses of neurodegenerative diseases are required to establish disease-modifying therapies. Obtaining a clear diagnosis of multiple system atrophy (MSA), a neurodegenerative disease, can be challenging because MSA has a number of clinical subtypes and many other diseases, known as mimics, are characterized by symptoms that are similar to those of MSA. This paper discusses the factors that make the clinical diagnosis of MSA difficult. Additionally, this paper introduces an attempt at the new clinical diagnostic criteria establishment in accord with recent clinical trials.