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Pathologic grading of mucoepidermoid carcinomas of the salivary gland and its effect on clinicopathologic follow-up: an institutional experience.
- Source :
-
Human pathology [Hum Pathol] 2020 Apr; Vol. 98, pp. 89-97. Date of Electronic Publication: 2020 Feb 06. - Publication Year :
- 2020
-
Abstract
- Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Differences inprognosis can be noted owing to the tumor grade determined using multiple grading schemes (2-tier: low- and high-grade vs. 3-tier: low-, intermediate-, and high-grade). We studied clinicopathologic features of MEC using a 3-tier grading system and retrospectively categorized cytologic diagnoses as per the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC).A total of 69 cases of MEC were identified, and most were seen in the parotid gland. Aggressive clinical behavior was seen in high-grade MEC compared with intermediate- and low-grade MEC. By fluorescence in situ hybridization (FISH) analysis, MAML2 rearrangements were seen in 78% of cases.The MSRSGC subcategorized the majority (63.8%) of MEC as salivary gland neoplasm of uncertain malignant potential, suspicious for malignancy, or malignant. Clustering intermediate- with low-grade cases did not significantly impact the clinical behavior. Both high-grade and oncocytic MEC can be MAML2 FISH negative.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Anoctamin-1 analysis
Biomarkers, Tumor analysis
Biomarkers, Tumor genetics
Biopsy
Carcinoma, Mucoepidermoid chemistry
Carcinoma, Mucoepidermoid genetics
Female
Gene Rearrangement
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Neoplasm Proteins analysis
Predictive Value of Tests
Retrospective Studies
Salivary Gland Neoplasms chemistry
Salivary Gland Neoplasms genetics
Trans-Activators genetics
Young Adult
Carcinoma, Mucoepidermoid pathology
Neoplasm Grading
Salivary Gland Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 98
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 32035991
- Full Text :
- https://doi.org/10.1016/j.humpath.2020.02.001