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Development of (G3-C12)-mediated camptothecin polymeric prodrug targeting to Galectin-3 receptor against androgen-independent prostate cancer.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2020 Apr 30; Vol. 580, pp. 119123. Date of Electronic Publication: 2020 Feb 05. - Publication Year :
- 2020
-
Abstract
- The development of small molecule anticancer drugs, with low water solubility and high toxicity, into polymeric prodrugs has developed into a promising strategy in clinical application. In this study, we synthesized a novel G3-C12-mediated esterase-sensitive tumor-targeting polymeric prodrug of camptothecin (CPT), P(OEGMA-co-CPT-co-G3-C12), and explored its anticancer activity against androgen-independent prostate cancer in vitro and in vivo. Compared to free CPT, the multifunctional polymeric prodrug demonstrated improved water solubility and stability, higher intracellular uptake, and enhanced cytotoxicity in DU145 cells in vitro. Furthermore, it displayed an improved accumulation in the tumor and an enhanced anticancer activity in vivo. Hence, P(OEGMA-co-CPT-co-G3-C12) could be a promising drug in the treatment of androgen-independent prostate cancer.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Camptothecin administration & dosage
Cell Line, Tumor
Cell Movement drug effects
Cell Movement physiology
Cell Survival drug effects
Cell Survival physiology
Dose-Response Relationship, Drug
Humans
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Polymers administration & dosage
Polymers metabolism
Prodrugs administration & dosage
Prostatic Neoplasms, Castration-Resistant drug therapy
Prostatic Neoplasms, Castration-Resistant pathology
Xenograft Model Antitumor Assays methods
Blood Proteins metabolism
Camptothecin metabolism
Drug Delivery Systems methods
Drug Development methods
Galectins metabolism
Prodrugs metabolism
Prostatic Neoplasms, Castration-Resistant metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 580
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 32035258
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2020.119123