4- n -Butylresorcinol-Based Linear and Graft Polymethacrylates for Arbutin and Vitamins Delivery by Micellar Systems.

A novel initiator, bromoester modified 4- n -butylresorcinol (4nBREBr ₂ ), was prepared and utilized in controlled atom transfer radical polymerization (ATRP) to obtain three series of amphiphilic copolymers. The V-shaped copolymers of methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA), and poly(ethylene glycol) methyl ether methacrylate (MPEGMA), abbreviated to P(HEMA- co -MMA), P(HEMA- co -MPEGMA), and P(MMA- co -MPEGMA), were synthesized. Moreover, P((HEMA- graft -PEG)- co -MMA) graft copolymers were prepared by combining the pre-polymerization modification of HEMA and a "click" reaction using a "grafting onto" approach. All copolymers could form micelles with encapsulated active substances (vitamin C (VitC), vitamin E (VitE), arbutin (ARB)), which are used in cosmetology. In vitro studies carried out in a PBS solution (pH 7.4) demonstrates that in most cases the maximum release of active substance was after 1 h. The polymeric systems presenting satisfactory encapsulation characteristics and release profiles are attractive micellar carriers of cosmetic substances, which show a positive effect on the skin condition.