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Reduced corneal nerve fibre length in prediabetes and type 2 diabetes: The Maastricht Study.
- Source :
-
Acta ophthalmologica [Acta Ophthalmol] 2020 Aug; Vol. 98 (5), pp. 485-491. Date of Electronic Publication: 2020 Feb 03. - Publication Year :
- 2020
-
Abstract
- Purpose: In individuals with diabetes, injury to the corneal nerve fibres predisposes to delayed corneal epithelial healing, reduced corneal sensitivity and corneal erosion. We investigated to what extent a reduction in corneal nerve fibre length (CNFL) is present in individuals with prediabetes or type 2 diabetes (DM2) compared with individuals with normal glucose metabolism (NGM).<br />Methods: Using composite images acquired by corneal confocal microscopy, we assessed total CNFL per mm <superscript>2</superscript> in the subbasal nerve plexus of the cornea in 134 participants (mean age 59 ± 8 years, 49% men, 87 NGM, 20 prediabetes, 27 DM2). Multivariable linear regression was used to assess the association between CNFL and glucose metabolism status, adjusted for age and sex.<br />Results: In individuals with type 2 diabetes, the mean CNFL was significantly reduced [β = -1.86 mm/mm <superscript>2</superscript> (95% CI -3.64 to -0.08), p = 0.04], as compared with individuals with normal glucose metabolism after adjustment for age and sex. Part of the reduction was present in individuals with prediabetes [β = -0.96 mm/mm <superscript>2</superscript> (95% CI -2.91 to 0.99), p = 0.34], with a linear trend of corneal nerve fibre reduction with severity of glucose metabolism status (p trend = 0.04).<br />Conclusions: A significant reduction in CNFL was found in individuals with DM2 compared with individuals with NGM. A trend of reduction in CNFL was observed between individuals with NGM and prediabetes. The reduction in corneal nerve fibre length could contribute to a delayed corneal healing and an increased risk for corneal complications after surgery.<br /> (© 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
Details
- Language :
- English
- ISSN :
- 1755-3768
- Volume :
- 98
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta ophthalmologica
- Publication Type :
- Academic Journal
- Accession number :
- 32017403
- Full Text :
- https://doi.org/10.1111/aos.14359