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A pneumonia outbreak associated with a new coronavirus of probable bat origin.
- Source :
-
Nature [Nature] 2020 Mar; Vol. 579 (7798), pp. 270-273. Date of Electronic Publication: 2020 Feb 03. - Publication Year :
- 2020
-
Abstract
- Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats <superscript>1-4</superscript> . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans <superscript>5-7</superscript> . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
- Subjects :
- Angiotensin-Converting Enzyme 2
Animals
Antibodies, Viral blood
Betacoronavirus metabolism
Betacoronavirus ultrastructure
COVID-19
Cell Line
China epidemiology
Chlorocebus aethiops
Female
Genome, Viral genetics
Humans
Male
Peptidyl-Dipeptidase A metabolism
Phylogeny
Severe acute respiratory syndrome-related coronavirus classification
Severe acute respiratory syndrome-related coronavirus genetics
SARS-CoV-2
Sequence Homology, Nucleic Acid
Severe Acute Respiratory Syndrome
Vero Cells
Betacoronavirus classification
Betacoronavirus genetics
Chiroptera virology
Coronavirus Infections epidemiology
Coronavirus Infections virology
Disease Outbreaks
Pneumonia, Viral epidemiology
Pneumonia, Viral virology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 579
- Issue :
- 7798
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 32015507
- Full Text :
- https://doi.org/10.1038/s41586-020-2012-7