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HER2 Gene Amplification in ER-positive HER2 Immunohistochemistry 0 or 1+ Breast Cancer With Early Recurrence.
- Source :
-
Anticancer research [Anticancer Res] 2020 Feb; Vol. 40 (2), pp. 645-652. - Publication Year :
- 2020
-
Abstract
- Background/aim: In estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, standard chemotherapies as well as adjuvant endocrine therapy might not be enough for prevention of early relapse.<br />Materials and Methods: We focused on ER-positive, HER2 immunohistochemistry (IHC) 0 or 1+ breast cancer, and retrospectively examined HER2 gene amplification and TP53 mutation in breast cancer tissues in patients with or without early recurrence. Post-relapse survival in patients with early recurrence was also analyzed by mutation status of HER2 and TP53.<br />Results: Surprisingly, amplification of the HER2 gene was found in 15% of patients with early recurrence. None of the patients without relapse had HER2-amplified tumors. Post-relapse survival in patients with HER2 gene amplification and/or TP53 mutation in primary tumors was shorter than that in patients without these mutations, especially among postmenopausal women.<br />Conclusion: HER2 gene amplification exists in ER-positive, HER2 IHC 0 or 1+ breast cancer in patients who developed early distant metastasis.<br /> (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adult
Aged
Breast Neoplasms enzymology
Breast Neoplasms pathology
Case-Control Studies
Female
Gene Amplification
Humans
Immunohistochemistry
Middle Aged
Mutation
Neoplasm Recurrence, Local enzymology
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Receptor, ErbB-2 metabolism
Receptors, Estrogen biosynthesis
Retrospective Studies
Tumor Suppressor Protein p53 genetics
Breast Neoplasms genetics
Neoplasm Recurrence, Local genetics
Receptor, ErbB-2 genetics
Receptors, Estrogen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 32014905
- Full Text :
- https://doi.org/10.21873/anticanres.13994