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Opposite Macrophage Polarization in Different Subsets of Ovarian Cancer: Observation from a Pilot Study.
- Source :
-
Cells [Cells] 2020 Jan 27; Vol. 9 (2). Date of Electronic Publication: 2020 Jan 27. - Publication Year :
- 2020
-
Abstract
- The role of the innate immune system in ovarian cancer is gaining importance. The relevance of tumor-associated macrophages (TAM) is insufficiently understood. In this pilot project, comprising the immunofluorescent staining of 30 biopsies taken from 24 patients with ovarian cancer, we evaluated the presence of total TAM (cluster of differentiation (CD) 68 expression), M1 (major histocompatibility complex (MHC) II expression), and M2 (anti-mannose receptor C type 1 (MRC1) expression), and the blood vessel diameter. We observed a high M1/M2 ratio in low-grade ovarian cancer compared to high-grade tumors, more total TAM and M2 in metastatic biopsies, and a further increase in total TAM and M2 at interval debulking, without beneficial effects of bevacizumab. The blood vessel diameter was indicative for M2 tumor infiltration (Spearman correlation coefficient of 0.65). These data mainly reveal an immune beneficial environment in low-grade ovarian cancer in contrast to high-grade serous ovarian cancer, where immune suppression is not altered by neoadjuvant therapy.<br />Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
- Subjects :
- Aged
Aged, 80 and over
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Bevacizumab pharmacology
Bevacizumab therapeutic use
Biopsy
Blood Vessels pathology
Female
Glucose Transporter Type 1 metabolism
Humans
Middle Aged
Neoplasm Grading
Ovarian Neoplasms blood supply
Ovarian Neoplasms diagnosis
Ovarian Neoplasms drug therapy
Pilot Projects
Cell Polarity
Macrophages pathology
Ovarian Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 32012728
- Full Text :
- https://doi.org/10.3390/cells9020305