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Maternal Prenatal Exposures in Pregnancy and Autism Spectrum Disorder: An Insight into the Epigenetics of Drugs and Diet as Key Environmental Influences.
- Source :
-
Advances in neurobiology [Adv Neurobiol] 2020; Vol. 24, pp. 143-162. - Publication Year :
- 2020
-
Abstract
- Autism spectrum disorder (ASD) is a rapidly growing global pandemic that affects an estimated 1 in 59-68 children. It is a complex disease with both genetic and environmental etiologies. Due to the rapid increase in the incidence of ASD, environmental causes for ASD are gaining attention. Efforts to probe several environmental exposures that could contribute to causing ASD are underway. In this regard, this chapter is directed towards understanding prenatal exposure to key environmental factors i.e., drugs and dietary nutrients that may act via the same molecular pathway - epigenetics as a potential etiological factor for ASD. Epigenetic regulation is a molecular mechanism known to be a significant contributor to neurodevelopmental disorders. It also offers a means to explain how environmental exposures can impact genetics. We discuss the impact of maternal exposures to certain drugs, and dietary intake, on the developing fetus during pregnancy. Maternal Exposure to some drugs during gestation are associated with a higher risk of ASD, while exposure to other dietary compounds may offer promise to rescue epigenetic regulatory insults related to ASD. However, more work in this important area is still required, nevertheless preliminary research already has important implications in the understanding, prevention and treatment of ASD.
- Subjects :
- Autism Spectrum Disorder prevention & control
Autism Spectrum Disorder therapy
Female
Humans
Infant, Newborn
Pregnancy
Autism Spectrum Disorder chemically induced
Autism Spectrum Disorder genetics
Diet adverse effects
Epigenesis, Genetic drug effects
Maternal Exposure adverse effects
Prenatal Exposure Delayed Effects chemically induced
Prenatal Exposure Delayed Effects genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2190-5215
- Volume :
- 24
- Database :
- MEDLINE
- Journal :
- Advances in neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 32006359
- Full Text :
- https://doi.org/10.1007/978-3-030-30402-7_5