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Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population.
- Source :
-
Scientific reports [Sci Rep] 2020 Jan 30; Vol. 10 (1), pp. 1487. Date of Electronic Publication: 2020 Jan 30. - Publication Year :
- 2020
-
Abstract
- Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher VAT or SAT amount among subjects free of metabolic diseases to identify possible contributing metabolic pathways. The study population comprised 491 subjects [mean (standard deviation): age 44.6 yrs (13.0), body mass index 25.4 kg/m² (3.6), 60.1% females] without diabetes, hypertension, dyslipidemia, the metabolic syndrome or impaired renal function. We associated MRI-derived fat amounts with mass spectrometry-derived metabolites in plasma and urine using linear regression models adjusting for major confounders. We tested for sex-specific effects using interactions terms and performed sensitivity analyses for the influence of insulin resistance on the results. VAT and SAT were significantly associated with 155 (101 urine) and 49 (29 urine) metabolites, respectively, of which 45 (27 urine) were common to both. Major metabolic pathways were branched-chain amino acid metabolism (partially independent of insulin resistance), surrogate markers of oxidative stress and gut microbial diversity, and cortisol metabolism. We observed a novel positive association between VAT and plasma levels of the potential pharmacological agent piperine. Sex-specific effects were only a few, e.g. the female-specific association between VAT and O-methylascorbate. In brief, higher VAT was associated with an unfavorable metabolite profile in a sample of healthy, mostly non-obese individuals from the general population and only few sex-specific associations became apparent.
- Subjects :
- Adipose Tissue diagnostic imaging
Adult
Alkaloids blood
Ascorbic Acid analogs & derivatives
Ascorbic Acid urine
Benzodioxoles blood
Biomarkers blood
Biomarkers urine
Cross-Sectional Studies
Female
Humans
Hydrocortisone blood
Hydrocortisone urine
Insulin Resistance
Intra-Abdominal Fat diagnostic imaging
Intra-Abdominal Fat metabolism
Intra-Abdominal Fat pathology
Magnetic Resonance Imaging
Male
Metabolome
Middle Aged
Organ Size
Piperidines blood
Polyunsaturated Alkamides blood
Sex Factors
Subcutaneous Fat diagnostic imaging
Subcutaneous Fat metabolism
Subcutaneous Fat pathology
Adipose Tissue metabolism
Adipose Tissue pathology
Metabolic Networks and Pathways
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32001750
- Full Text :
- https://doi.org/10.1038/s41598-020-58430-8