In vitro characterization of virulence factors among species of the Candida parapsilosis complex.

Authors :: Ataides FS
Costa CR
Santos AS
Freitas VAQ
Silva TC
Zara ALSA
Jesuino RSA
Silva MRR
Source :: Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2020 Jan 27; Vol. 53, pp. e20190336. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Introduction: Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence.<br />Methods: The hydrolytic enzyme activity, biofilm production, and adhesion to epithelial cells were analyzed in 87 C. parapsilosis complex strains.<br />Results: Among the studied isolates, 97.7%, 63.2%, and 82.8% exhibited very strong proteinase, esterase, and hemolysin activity, respectively. All the C. parapsilosis complex isolates produced biofilms and presented an average adherence of 96.0 yeasts/100 epithelial cells.<br />Conclusions: Our results show that Candida parapsilosis complex isolates showed different levels of enzyme activity, biofilm production, and adhesion to epithelial cells.

Subjects :: Biofilms growth & development
Candida parapsilosis classification
Candida parapsilosis enzymology
Candida parapsilosis isolation & purification
Cell Adhesion
Humans
Hydrolases biosynthesis
Mycological Typing Techniques
Candida parapsilosis pathogenicity
Virulence Factors analysis

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