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Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C.
- Source :
-
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2020 Jan 27; Vol. 53, pp. e20190210. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Introduction: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C.<br />Methods: Patients (159) with chronic hepatitis C of both genders were analyzed.<br />Results: Women showed association between HPA-3 polymorphisms and RM.<br />Conclusions: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Antigens, Human Platelet blood
Female
Genotype
Humans
Male
Middle Aged
Risk Factors
Young Adult
Antigens, Human Platelet genetics
Hepatitis C, Chronic blood
Hepatitis C, Chronic complications
Polymorphism, Genetic genetics
Rheumatic Diseases blood
Rheumatic Diseases etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1678-9849
- Volume :
- 53
- Database :
- MEDLINE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Publication Type :
- Academic Journal
- Accession number :
- 31994660
- Full Text :
- https://doi.org/10.1590/0037-8682-0210-2019