9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds.

Authors :: Calogero F
Borrelli S
Speciale G
Christodoulou MS
Cartelli D
Ballinari D
Sola F
Albanese C
Ciavolella A
Passarella D
Cappelletti G
Pieraccini S
Sironi M
Source :: ChemPlusChem [Chempluschem] 2013 Jul; Vol. 78 (7), pp. 663-669. Date of Electronic Publication: 2013 May 13.
Publication Year :: 2013
Abstract: The introduction of a hydrophobic group at position 7 of 9-fluorenone-2-carboxylic acid generates new tubulin binders, the design of which is suggested by modeling studies. The synthesis is based on the use of 2,7-dibromo-fluorenone as starting material. The antiproliferative activity on two different cell lines, fluorescent microscopy, flow cytometry, and sedimentation assay tests confirmed the supposed mechanism.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)