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Clinical Characteristics of the Charles Bonnet Syndrome in Patients with Neovascular Age-Related Macular Degeneration: The Importance of Early Detection.
- Source :
-
Ophthalmic research [Ophthalmic Res] 2020; Vol. 63 (5), pp. 466-473. Date of Electronic Publication: 2020 Jan 27. - Publication Year :
- 2020
-
Abstract
- Purpose: We investigated the characteristics, prognosis, and clinical outcome of the Charles Bonnet syndrome (CBS) in patients with neovascular age-related macular degeneration (AMD).<br />Methods: Five hundred psychiatrically healthy patients with neovascular AMD were screened for CBS. The individuals that fulfilled the inclusion criteria were systematically interviewed using a structured questionnaire that covered the impact, prognosis, risk factors, phenomenology, symptoms, and knowledge about the syndrome. A control group of 45 patients was used for comparison. Demographic data, current medication, and ocular risk factors were collected in all patients.<br />Results: Forty-five patients with CBS were identified. The majority of patients reported images that consisted of colored (62%) animals (44%) or faces (42%) that lasted for seconds (53%). Most patients reported a self-limited disease with a median duration of symptoms between 9 and 11.5 months, with only 7% knowing about CBS at symptom onset. The degree of visual deficit did not predict the characteristics, complexity, frequency, duration, or impact of visual hallucinations. One-third of patients reported negative outcome, which was associated with shorter duration of CBS (p = 0.023), fear-inducing images (p < 0.001), and impact on daily activities (p = 0.015).<br />Conclusion: The prevalence of CBS in neovascular AMD patients is high and clinically relevant. Patients with recent onset of visual hallucinations and describing fear-inducing images are at greater risk for negative outcome. Periodic screening may minimize the negative consequences of this disease.<br /> (© 2020 S. Karger AG, Basel.)
- Subjects :
- Aged
Aged, 80 and over
Charles Bonnet Syndrome complications
Charles Bonnet Syndrome epidemiology
Female
Follow-Up Studies
Humans
Male
Portugal epidemiology
Prevalence
Prognosis
Retrospective Studies
Risk Factors
Surveys and Questionnaires
Wet Macular Degeneration complications
Wet Macular Degeneration epidemiology
Charles Bonnet Syndrome diagnosis
Early Diagnosis
Visual Acuity
Wet Macular Degeneration diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0259
- Volume :
- 63
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ophthalmic research
- Publication Type :
- Academic Journal
- Accession number :
- 31986513
- Full Text :
- https://doi.org/10.1159/000506137