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Peritheliomatous pattern: A diagnostic clue for diagnosing metastatic melanoma in cytology.
- Source :
-
Cancer cytopathology [Cancer Cytopathol] 2020 Apr; Vol. 128 (4), pp. 260-268. Date of Electronic Publication: 2020 Jan 27. - Publication Year :
- 2020
-
Abstract
- Background: A peritheliomatous pattern (PP) in tumors is characterized by a sheath of viable tumor cells closely surrounding a central blood vessel. In the authors' cytology practice, such a PP has been recognized in several metastatic melanoma specimens. The aim of this study was to evaluate the frequency of a PP in cytology samples of melanoma in comparison with other tumors.<br />Methods: Eighty archival fine-needle aspiration (FNA) cases of metastatic melanoma were compared with 65 control cases (35 poorly differentiated/metastatic carcinomas, 15 lymphomas, and 15 recurrent/metastatic/high-grade sarcomas). Cytologic findings were correlated with corresponding histologic specimens, which were available for 44 cases (55%) in the melanoma group and for 23 cases (35.38%) in the control group. All slides were examined for a PP and were semiquantitatively graded for comparison.<br />Results: A PP was present in 51.3% of the cytologic preparations (n = 41) among the melanoma group cases, whereas in the control group, a PP was present in only 3.1% of the cases (n = 2). A PP was present in 65.9% of melanomas with available histologic sections (n = 29) and in 8.7% of tissue samples from the control group (n = 2). A PP was seen more often in cell blocks than direct smear preparations (51.3% vs 40.0%) from patients with melanoma.<br />Conclusions: The presence of a characteristic PP can be helpful in diagnosing melanoma in FNA samples because it was present in almost half of the metastatic melanoma cases in this study and was rarely present in other tumor types. A PP is easier to recognize and more often presents in cell blocks than aspirate smears. Ancillary studies such as immunohistochemistry are helpful for excluding other entities that may exhibit a PP.<br /> (© 2020 American Cancer Society.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Biopsy, Fine-Needle standards
Biopsy, Fine-Needle statistics & numerical data
Cytodiagnosis standards
Cytodiagnosis statistics & numerical data
Female
Humans
Immunohistochemistry methods
Ki-67 Antigen metabolism
Lymphoma classification
Lymphoma metabolism
Male
Melanoma metabolism
Melanoma pathology
Middle Aged
Neoplasm Metastasis
Pathology, Clinical standards
Pathology, Clinical statistics & numerical data
Biopsy, Fine-Needle methods
Cytodiagnosis methods
Lymphoma diagnosis
Melanoma diagnosis
Pathology, Clinical methods
Subjects
Details
- Language :
- English
- ISSN :
- 1934-6638
- Volume :
- 128
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer cytopathology
- Publication Type :
- Academic Journal
- Accession number :
- 31985897
- Full Text :
- https://doi.org/10.1002/cncy.22241