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Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2020 Mar 24; Vol. 82 (3), pp. 350-359. Date of Electronic Publication: 2020 Jan 27. - Publication Year :
- 2020
-
Abstract
- Dinotefuran (DIN) belongs to the neonicotinoids (NNs), a class of globally applied pesticides originally developed to exhibit selective toxicity in insects. However, several reports have suggested that NNs also exert neurotoxic effects in mammals. We previously demonstrated neurobehavioral effects of DIN on mice under non-stressful conditions. For further toxicity assessments in the present study, we investigated the effects of DIN on mice exposed to stressful conditions. After subacutely administering a no-observed-effect-level (NOEL) dose of DIN and/or chronic unpredictable mild stress (CUMS) to mice, we conducted three behavioral tests (i.e., open field test [OFT], tail suspension test [TST] and forced swimming test [FST]). In addition, serotonin (5-HT) and tryptophan hydroxylase 2 (TPH2) of the dorsal raphe nuclei (DRN) and median raphe nuclei (MRN) and tyrosine hydroxylase (TH) of the ventral tegmental area and substantia nigra (SN) were evaluated immunohistochemically. A NOEL dose of DIN or CUMS alone increased of the total distance in OFT, decreased or increased the immobility time in TST or FST, respectively, and increased the positive intensity of 5-HT and TPH2 in the DRN/MRN, and TH in the SN. These changes were suppressed under the conditions of combined exposure to DIN and CUMS, though the blood corticosterone level was increased depending on the blood DIN values and the presence of CUMS. The present study suggests the multifaceted toxicity of the neurotoxin DIN.
- Subjects :
- Animals
Behavior, Animal drug effects
Corticosterone blood
Emotions physiology
Exploratory Behavior drug effects
Guanidines blood
Hindlimb Suspension
Insecticides toxicity
Male
Mice, Inbred C57BL
Neonicotinoids blood
Nitro Compounds blood
Serotonin metabolism
Swimming
Tryptophan Hydroxylase metabolism
Tyrosine 3-Monooxygenase metabolism
Brain metabolism
Guanidines toxicity
Neonicotinoids toxicity
Nitro Compounds toxicity
Stress, Psychological
Subjects
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 31983702
- Full Text :
- https://doi.org/10.1292/jvms.19-0635