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Iron Packaging Regulations in the United States and Pediatric Morbidity: A Retrospective Cohort Study.
- Source :
-
Clinical pediatrics [Clin Pediatr (Phila)] 2020 May; Vol. 59 (4-5), pp. 375-379. Date of Electronic Publication: 2020 Jan 24. - Publication Year :
- 2020
-
Abstract
- Iron poisoning was a leading cause of pediatric morbidity and mortality. We sought to assess whether the removal of strict iron packaging requirements in 2003 resulted in an increase in iron-related morbidity and mortality in pediatric exposures. We performed a retrospective cohort study utilizing the National Poison Data System from 2000 to 2017. A total of 4110 exposures met inclusion criteria: 847 from before (2000-2003) and 3263 after removal of unit-dose package regulations (2004-2017). The incidence of any marker of severity (7.2% vs 3.8%; odds ratio = 0.51, 95% confidence interval = 0.37-0.69) and frequency of deferoxamine use were both higher in the early time period (2.6% vs 1.0%; odds ratio = 0.38, 95% confidence interval = 0.22-0.66). There was no difference in the frequency of key serious effects (acidosis, elevated transaminases, hypotension). Despite removal of iron packaging regulations in the United States, there continues to be a decrease in the incidence of severe iron exposures in children.
Details
- Language :
- English
- ISSN :
- 1938-2707
- Volume :
- 59
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Clinical pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 31976760
- Full Text :
- https://doi.org/10.1177/0009922819901010