Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib.

Authors :: Christodoulou MS
Mori M
Pantano R
Alfonsi R
Infante P
Botta M
Damia G
Ricci F
Sotiropoulou PA
Liekens S
Botta B
Passarella D
Source :: ChemPlusChem [Chempluschem] 2015 Jun; Vol. 80 (6), pp. 938-943. Date of Electronic Publication: 2015 Feb 27.
Publication Year :: 2015
Abstract: The design and the preparation of a small library of 1,4-diphenyl-1,2,3-triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened protein is part of the hedgehog signaling pathway that is inhibited by the lead compound Vismodegib. Based on molecular modeling simulations, seven triazole derivatives of Vismodegib are synthesized and their biological effect on different endothelial, cancer, and cancer stem cell lines is reported.<br /> (Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)