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Specific IgA and CLA + T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2020 Jul; Vol. 140 (7), pp. 1364-1370.e1. Date of Electronic Publication: 2020 Jan 21. - Publication Year :
- 2020
-
Abstract
- Streptococcus pyogenes tonsillar infection is well known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis pathology, the interaction between their specific immune responses has not been deeply explored. This work aims to address and characterize the presence of humoral responses against S. pyogenes in patients with psoriasis and its putative association with cytokine responses detected in vitro in our psoriasis ex vivo model, based on the coculture of cutaneous lymphocyte-associated antigen <superscript>+/-</superscript> T cells with autologous epidermal cells. Patients with psoriasis presented increased IgA response to S. pyogenes when compared with control subjects. In patients with plaque psoriasis, despite being negative for anti-streptolysin O antibody titer, IgA plasma levels against S. pyogenes correlated with cutaneous lymphocyte-associated antigen <superscript>+</superscript> T-cell-dependent IL-17F response in vitro. No association is observed for IgG levels in plaque psoriasis. Similar association is observed for IgA anti-S. pyogenes extract and IL-17A in patients with guttate psoriasis. We propose S. pyogenes-specific IgA as a potential new perspective for better understanding the role of S. pyogenes in psoriasis development.<br /> (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Cytokines immunology
Epidermal Cells pathology
Female
Humans
Immunoglobulin A blood
Immunoglobulin G blood
Male
Middle Aged
Oligosaccharides immunology
Palatine Tonsil immunology
Psoriasis blood
Psoriasis immunology
Sialyl Lewis X Antigen analogs & derivatives
Sialyl Lewis X Antigen immunology
Skin pathology
Streptococcal Infections blood
Streptococcal Infections microbiology
Young Adult
Immunoglobulin A immunology
Interleukin-17 immunology
Psoriasis microbiology
Streptococcal Infections immunology
Streptococcus pyogenes
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 140
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 31972247
- Full Text :
- https://doi.org/10.1016/j.jid.2019.12.022