Apoptotic cell characteristics of rat brain microvascular endothelia induced by different degrees of hypoperfusion.

Authors :: Tian S
Wu J
Li C
Zhang B
Jiang C
Liu G
Chen Y
Qin W
Li F
Bai Y
Wu Y
Zhu Y
Source :: International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2017 Nov 01; Vol. 10 (11), pp. 11360-11368. Date of Electronic Publication: 2017 Nov 01 (Print Publication: 2017).
Publication Year :: 2017
Abstract: Hypoperfusion is one of the common causes of ischemic stroke. In this study, decreased blood perfusion and neurological damage were confirmed in ischemic rats. Further, the effect of different perfusion was researched in vivo. We found that hypoperfusion promoted the apoptosis of rats brain microvascular endothelial cells, and the more serious of hypoperfusion, the more obvious of apoptosis. At the same time, this process was related to Tie-2 receptor on cell membranes and Caspase-3 apoptotic pathways. Hemodynamics was one factors affecting the cerebral infarction.<br />Competing Interests: None.<br /> (IJCEP Copyright © 2017.)

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