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Pharmacogenetics in Practice: Estimating the Clinical Actionability of Pharmacogenetic Testing in Perioperative and Ambulatory Settings.
- Source :
-
Clinical and translational science [Clin Transl Sci] 2020 May; Vol. 13 (3), pp. 618-627. Date of Electronic Publication: 2020 Feb 12. - Publication Year :
- 2020
-
Abstract
- Most literature describing pharmacogenetic implementations are within academic medical centers and use single-gene tests. Our objective was to describe the results and lessons learned from a multisite pharmacogenetic pilot that utilized panel-based testing in academic and nonacademic settings. This was a retrospective analysis of 667 patients from a pilot in 4 perioperative and 5 outpatient cardiology clinics. Recommendations related to 12 genes and 65 drugs were classified as actionable or not actionable. They were ascertained from Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines and US Food and Drug Administration (FDA) labeling. Patients displayed a high prevalence of actionable results (88%, 99%) and use of medications (28%, 46%) with FDA or CPIC recommendations, respectively. Sixteen percent of patients had an actionable result for a current medication per CPIC compared with 5% per FDA labeling. A systematic approach by a health system may be beneficial given the quantity and diversity of patients affected.<br /> (© 2020 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.)
- Subjects :
- Aged
Ambulatory Care standards
District of Columbia
Female
Humans
Male
Maryland
Middle Aged
Perioperative Care standards
Pharmacogenomic Testing standards
Pilot Projects
Practice Guidelines as Topic
Practice Patterns, Physicians' standards
Precision Medicine methods
Precision Medicine standards
Retrospective Studies
United States
United States Food and Drug Administration standards
Ambulatory Care statistics & numerical data
Perioperative Care statistics & numerical data
Pharmacogenomic Testing statistics & numerical data
Practice Patterns, Physicians' statistics & numerical data
Precision Medicine statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1752-8062
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and translational science
- Publication Type :
- Academic Journal
- Accession number :
- 31961467
- Full Text :
- https://doi.org/10.1111/cts.12748