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Changing epidemiology of acute liver failure in Italy: a single-center experience over 25 years.
- Source :
-
Minerva medica [Minerva Med] 2020 Aug; Vol. 111 (4), pp. 330-336. Date of Electronic Publication: 2020 Jan 20. - Publication Year :
- 2020
-
Abstract
- Background: Acute liver failure (ALF) is a rare but often lethal syndrome. In Italy, recent data on its incidence and causes are lacking. We report here the epidemiological analysis of ALF cases observed in Campania, a Southern Italian region, over the last 25 years.<br />Methods: Medical records of ALF cases hospitalized from 1992 to 2018 were retrospectively analyzed.<br />Results: Two hundred ten ALF cases occurred during 1992-2018: 103 (49%) hepatitis B virus (HBV)-related (including 5 cases also infected with Delta virus), 39 (19%) from undetermined cause, 36 (17%) drug-induced, 11 (5%) Wilson's disease-associated, 8 (4%) hepatitis A virus (HAV)-related and 12 (6%) from other causes. Separate time-periods analysis of data showed a significant progressive decrease in ALF incidence mainly attributable to a decline of HBV and other viruses etiology. Already before 2010, HAV or Delta virus-related cases have no longer been observed. No hepatitis C or E virus-related ALF was detected through the study period. A progressive decrease in frequency of ALF due to undetermined causes or drug was also evident.<br />Conclusions: A decrease in ALF incidence and a changing in its etiology were observed in Campania during 1992-2018. Both results were likely mainly due to 1991 introduction of HBV universal vaccination and may be considered generalizable nationwide.
Details
- Language :
- English
- ISSN :
- 1827-1669
- Volume :
- 111
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Minerva medica
- Publication Type :
- Academic Journal
- Accession number :
- 31958920
- Full Text :
- https://doi.org/10.23736/S0026-4806.19.06331-6