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Vaginal Microbiota Transplantation: The Next Frontier.

Authors :
DeLong K
Zulfiqar F
Hoffmann DE
Tarzian AJ
Ensign LM
Source :
The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics [J Law Med Ethics] 2019 Dec; Vol. 47 (4), pp. 555-567.
Publication Year :
2019

Abstract

The success of fecal microbiota transplantation (FMT) as a treatment for Clostrioides difficile infection (CDI) has stirred excitement about the potential for microbiota transplantation as a therapy for a wide range of diseases and conditions. In this article, we discuss vaginal microbiota transplantation (VMT) as "the next frontier" in microbiota transplantation and identify the medical, regulatory, and ethical challenges related to this nascent field. We further discuss what we anticipate will be the first context for testing VMT in clinical trials, prevention of the recurrence of a condition referred to as bacterial vaginosis (BV). We also compare clinical aspects of VMT with FMT and comment on how VMT may be similar to or different from FMT in ways that may affect research design and regulatory decisions.

Details

Language :
English
ISSN :
1748-720X
Volume :
47
Issue :
4
Database :
MEDLINE
Journal :
The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
Publication Type :
Academic Journal
Accession number :
31957577
Full Text :
https://doi.org/10.1177/1073110519897731