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Antifungal Styryloquinolines as Candida albicans Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors.

Authors :
Cieslik W
Szczepaniak J
Krasowska A
Musiol R
Source :
Molecules (Basel, Switzerland) [Molecules] 2020 Jan 15; Vol. 25 (2). Date of Electronic Publication: 2020 Jan 15.
Publication Year :
2020

Abstract

Styrylquinolines are heterocyclic compounds that are known for their antifungal and antimicrobial activity. Metal complexation through hydroxyl groups has been claimed to be a plausible mechanism of action for these types of compounds. A series of novel structures with protected hydroxyl groups have been designed and synthesized to verify the literature data. Their antifungal activity against wild-type Candida albicans strain and mutants with silenced efflux pumps activity has been determined. Combinations with fluconazole revealed synergistic interactions that were dependent on the substitution pattern. These results open a new route for designing active antifungal agents on a styrylquinoline scaffold.

Details

Language :
English
ISSN :
1420-3049
Volume :
25
Issue :
2
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
31952124
Full Text :
https://doi.org/10.3390/molecules25020345