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(Sterol)ized Immunity: Could PI3K/AKT3 Be the Answer?
- Source :
-
Immunity [Immunity] 2020 Jan 14; Vol. 52 (1), pp. 4-6. - Publication Year :
- 2020
-
Abstract
- Type I interferons (IFNs) can reprogram the cholesterol biosynthetic pathway to facilitate innate immune responses. In this issue of Immunity, Xiao et al. (2020) reveal that type I IFN signaling and 7-dehydrocholesterol (7-DHC) accumulation form a positive feedback loop to amplify innate immune responses to control viral infections by activating AKT3.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-4180
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 31951549
- Full Text :
- https://doi.org/10.1016/j.immuni.2019.12.017