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Artemisinin-derived hybrids and their anticancer activity.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2020 Feb 15; Vol. 188, pp. 112044. Date of Electronic Publication: 2020 Jan 08. - Publication Year :
- 2020
-
Abstract
- The emergence of drug-resistance and the low specificity of anticancer agents are the major challenges in the treatment of cancer and can result in many side effects, creating an urgent demand to develop novel anticancer agents. Artemisinin-derived compounds, bearing a peroxide-containing sesquiterpene lactone moiety, could form free radicals with high reactivity and possess diverse pharmaceutical properties including in vitro and in vivo anticancer activity besides their typical antimalarial activity. Hybrid molecules have the potential to improve the specificity and overcome the drug resistance, therefore hybridization of artemisinin skeleton with other anticancer pharmacophores may provide novel anticancer candidates with high specificity and great potency against drug-resistant cancers. The review outlines the recent advances of artemisinin-derived hybrids as potential anticancer agents, and the structure-activity relationships are also discussed to provide an insight for rational designs of novel hybrids with high activity.<br /> (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Artemisinins chemical synthesis
Artemisinins chemistry
Cell Proliferation drug effects
Drug Resistance, Neoplasm drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Neoplasms pathology
Structure-Activity Relationship
Antineoplastic Agents pharmacology
Artemisinins pharmacology
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 188
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31945642
- Full Text :
- https://doi.org/10.1016/j.ejmech.2020.112044