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Small fiber neuropathy in unexpected clinical settings: a review.
- Source :
-
Muscle & nerve [Muscle Nerve] 2020 Aug; Vol. 62 (2), pp. 167-175. Date of Electronic Publication: 2020 Feb 04. - Publication Year :
- 2020
-
Abstract
- Small fiber neuropathy (SFN) is being recognized with increasing frequency in neuromuscular practice due to improved diagnostic techniques. Although there are some common etiologies, up to one-third of cases are considered idiopathic. In recent years, several disorders have unexpectedly been reported in association with SFN, on clinical grounds and complementary investigations, including quantitative sensory testing, intraepidermal nerve fiber density and confocal corneal microscopy. Knowledge of these disorders is important in clinical practice as increased awareness enables prompt diagnosis of SFN in these settings and early optimal therapeutic management of affected patients. Furthermore, these new developments may lead to a better understanding of the pathophysiologic mechanisms underlying SFN in these different disorders as well as, in some cases, an expanded spectrum of affected organs and systems. This article reviews these reported associations, their possible pathophysiologic bases, and the potential resulting management implications.<br /> (© 2020 Wiley Periodicals, Inc.)
- Subjects :
- Biopsy
Cornea innervation
Cornea pathology
Ehlers-Danlos Syndrome complications
Epidermis innervation
Epidermis pathology
Evoked Potentials
Humans
Lewy Body Disease complications
Microscopy, Confocal
Nerve Fibers, Unmyelinated pathology
Papillomavirus Vaccines adverse effects
Psychophysics
REM Sleep Behavior Disorder complications
Small Fiber Neuropathy chemically induced
Small Fiber Neuropathy diagnosis
Small Fiber Neuropathy pathology
Amyotrophic Lateral Sclerosis complications
Fibromyalgia complications
Guillain-Barre Syndrome complications
Parkinson Disease complications
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating complications
Small Fiber Neuropathy complications
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4598
- Volume :
- 62
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 31943276
- Full Text :
- https://doi.org/10.1002/mus.26808