Back to Search
Start Over
Correlations between maximum standardized uptake value measured via 18 F-fluorodeoxyglucose positron emission tomography/computed tomography and clinical variables and biochemical indicators in adult lymphoma.
- Source :
-
Journal of cancer research and therapeutics [J Cancer Res Ther] 2019; Vol. 15 (7), pp. 1581-1588. - Publication Year :
- 2019
-
Abstract
- Objectives: The aim of the current study was to investigate whether the maximum standardized uptake value (SUVmax) measured by <superscript>18</superscript> F-fluorodeoxyglucose ( <superscript>18</superscript> F-FDG) positron emission tomography (PET)/computed tomography (CT) could discriminate between aggressive and indolent non-Hodgkin lymphomas (NHLs) and correlations between the SUVmax and clinical variables and serum biochemical indicators in adult lymphoma.<br />Methods: A total of 103 patients with lymphoma confirmed by biopsy, pretreatment <superscript>18</superscript> F-FDG PET/CT scans, and a complete medical record were retrospectively enrolled in the study. Clinical variables that were evaluated included stage, pathological subtype, International Prognostic Index (IPI) score, and Ki-67 index, as well as serum biochemical indicators (e.g., lactate dehydrogenase [LDH] and erythrocyte sedimentation rate [ESR]) and metabolic parameters (e.g., SUVmax of the biopsy site on PET/CT). Correlations between SUVmax and clinical variables and serum biochemical indicators were investigated.<br />Results: Of the 103 patients, 84 had NHL and 19 had Hodgkin lymphoma. The area under the receiver operating characteristic curve for examining the accuracy of SUVmax with regard to distinguishing between aggressive and indolent NHLs was 0.94 (95% confidence interval: 0.89-0.99), suggesting that SUVmax was a useful predictor of diagnosis. A cutoff value of 8.5 yielded a sensitivity of 76.3% and specificity of 92.0%. The SUVmax mean ± standard deviation of NHL (9.8 ± 6.0, range: 1.8-28.1) was higher than that of HL (7.5 ± 2.8, range: 3.5-13.9) (P = 0.016), but there was no statistically significant difference in SUVmax between NHL and HL (P > 0.05). SUVmax of the biopsy site was strongly positively correlated with Ki-67 index (r = 0.813, P < 0.001) and moderately positively correlated with IPI score (r = 0.332, P = 0.002), but it was not significantly correlated with clinical stage, LDH, or ESR (P > 0.05).<br />Conclusions: <superscript>18</superscript> F-FDG PET/CT may yield reliable measurements of tumor proliferation, and an SUVmax >8.5 may distinguish between aggressive and indolent NHLs. In adults with newly diagnosed lymphoma, SUVmax correlates with Ki-67 index and IPI score.<br />Competing Interests: None
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biopsy
Female
Humans
Image Processing, Computer-Assisted
Ki-67 Antigen metabolism
Male
Middle Aged
Neoplasm Staging
ROC Curve
Retrospective Studies
Young Adult
Biomarkers
Fluorodeoxyglucose F18 metabolism
Lymphoma diagnosis
Lymphoma metabolism
Positron Emission Tomography Computed Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4138
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 31939441
- Full Text :
- https://doi.org/10.4103/jcrt.JCRT_671_18