Clinical significance of USP7 and EZH2 in predicting prognosis of laryngeal squamous cell carcinoma and their possible functional mechanism.

Authors :: Zhang MJ
Chen DS
Li H
Liu WW
Han GY
Han YF
Source :: International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2019 Jun 01; Vol. 12 (6), pp. 2184-2194. Date of Electronic Publication: 2019 Jun 01 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent cancer types in the world. The ubiquitin specific protease 7 (USP7), a kind of deubiquitylating enzyme, has been reported to play multifaceted roles in different tumor types. EZH2 has been found to be highly expressed in various malignantcells and high expression of EZH2 is closely related to tumor growth infiltration, lymph node involvement, clinical stage, and poor prognosis. The aim of this study was to investigate the expression and function of USP7 and EZH2 in LSCC.<br />Case Presentation: Immunohistochemical staining and histochemical staining were performed to explore the expression of USP7 and EZH2 in both LSCC tissues and adjacent normal laryngeal tissues. Chi-square test, univariate analysis, and multivariate analysis were conducted to statistically evaluate the clinical significance of USP7 and EZH2.<br />Conclusions: USP7and EZH2 affects LSCC evolution; USP7 and EZH2 were upregulated in LSCC tissues, which can serve as independent prognostic predictors, and potential therapeutic targets for LSCC.<br />Competing Interests: None.<br /> (IJCEP Copyright © 2019.)

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