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Deoxofluorination of (Hetero)aromatic Acids.

Authors :
Trofymchuk S
Bugera MY
Klipkov AA
Razhyk B
Semenov S
Tarasenko K
Starova VS
Zaporozhets OA
Tananaiko OY
Alekseenko AN
Pustovit Y
Kiriakov O
Gerus II
Tolmachev AA
Mykhailiuk PK
Source :
The Journal of organic chemistry [J Org Chem] 2020 Mar 06; Vol. 85 (5), pp. 3110-3124. Date of Electronic Publication: 2020 Jan 27.
Publication Year :
2020

Abstract

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Details

Language :
English
ISSN :
1520-6904
Volume :
85
Issue :
5
Database :
MEDLINE
Journal :
The Journal of organic chemistry
Publication Type :
Academic Journal
Accession number :
31928000
Full Text :
https://doi.org/10.1021/acs.joc.9b03011