Lipoteichoic acid reduces antioxidant enzymes in H9c2 cells.

Authors :: Fernández-Rojas B
Vázquez-Cervantes GI
Pedraza-Chaverri J
Gutiérrez-Venegas G
Source :: Toxicology reports [Toxicol Rep] 2019 Dec 30; Vol. 7, pp. 101-108. Date of Electronic Publication: 2019 Dec 30 (Print Publication: 2020).
Publication Year :: 2019
Abstract: Infective endocarditis (IE) is an illness where the heart is invaded by bacteria, like Streptococcal and Staphylococcal species that contain lipoteichoic acid (LTA) related to an essential role in this disease. This study is the first in evaluating antioxidant enzyme levels in embryonic cardiomyocyte cell line (H9c2) induced by LTA from Streptococcus sanguinis . LTA increased reactive oxygen species (ROS) and reduced the levels of the antioxidant enzymes glutathione peroxidase, superoxide dismutase (SOD)-1 and catalase (CAT) but did not affect glutathione content. At the highest LTA concentration (15 μg/ml), SOD-1 and CAT levels did not change, and this effect was related to the induction of mRNA levels of Nrf2 induced by LTA. These results suggest that low antioxidant enzyme levels and ROS production could be related to IE.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (© 2019 Published by Elsevier B.V.)