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Foetal and neonatal alloimmune thrombocytopenia - The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome.
- Source :
-
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2020 Feb; Vol. 59 (1), pp. 102707. Date of Electronic Publication: 2019 Dec 31. - Publication Year :
- 2020
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Abstract
- Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The HLA molecule encoded by the HLA-DRA/DRB3*01:01 genes seems to be of crucial importance for initiating the immune response against HPA-1a. The HLA-DRB3*01:01 carrier status is not only important as a risk factor for immunisation, but does also have a significant impact on foetal/neonatal outcome. The possible role of HLA-DRB3*01:01 typing as tool for risk stratification is discussed.<br />Competing Interests: Declaration of Competing Interest JKK belong to a group of founders and owners of Prophylix AS, a Norwegian biotech company which has produced a hyperimmune anti-HPA-1a IgG (NAITgam) for the prevention of HPA-1a-immunisation and FNAIT. JKK is also a consultant for Rallybio IPA, LLC a US biotech company which will continue the development of NAITgam until licensure.<br /> (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1473-0502
- Volume :
- 59
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
- Publication Type :
- Academic Journal
- Accession number :
- 31919011
- Full Text :
- https://doi.org/10.1016/j.transci.2019.102707