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Utility of the Modified Isolated-check Visual Evoked Potential Technique in Functional Glaucoma Assessment.
- Source :
-
Journal of glaucoma [J Glaucoma] 2020 Apr; Vol. 29 (4), pp. 258-263. - Publication Year :
- 2020
-
Abstract
- PRE[COMBINING ACUTE ACCENT]CIS:: Cortical response to low-contrast stimuli, as measured by isolated-check visual evoked potential (icVEP) technology, has the potential to provide functional assessment that may complement standard achromatic perimetry in assessing glaucomatous change.<br />Purpose: To evaluate the utility of modified icVEP testing in detecting functional glaucomatous damage.<br />Materials and Methods: Subjects who met predetermined criteria of controls, glaucoma suspects, preperimetric glaucoma, or glaucoma were enrolled in this prospective cross-sectional study from a single tertiary care center. Glaucoma patients were further categorized as early, moderate, advanced, or severe on the basis of Hodapp-Anderson-Parrish criteria. icVEP testing was performed with ten 2-second runs per qualified eye using the EvokeDx testing software. Multivariate statistics were used to calculate signal-to-noise ratios (SNR) and perform outlier analysis.<br />Results: In total, 140 eyes met criteria (mean±SD; age of 63±14 y; 49% male; logMAR visual acuity, 0.11±0.089). There was no significant difference in age, sex, or logMAR visual acuity among the groups. Controls had a significantly higher SNR than all other groups (P<0.003), including patients with preperimetric glaucoma. Among those with glaucoma, the early glaucoma patients had significantly higher SNR than the moderate, advanced, or severe glaucoma cohorts (P<0.04). The optimal SNR cutoff for differentiating between glaucomatous and nonglaucomatous eyes was 0.95, both with (sensitivity 82%, specificity 76%) and without (sensitivity 82%, specificity 100%) glaucoma suspects included in analysis.<br />Conclusions: icVEP technology has the potential to complement standard achromatic perimetry in functional assessment of glaucomatous defects.
- Subjects :
- Adult
Aged
Cross-Sectional Studies
Female
Humans
Intraocular Pressure physiology
Male
Middle Aged
Ocular Hypertension physiopathology
Prospective Studies
Visual Acuity physiology
Visual Cortex physiopathology
Visual Field Tests methods
Visual Fields physiology
Evoked Potentials, Visual physiology
Glaucoma physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-481X
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of glaucoma
- Publication Type :
- Academic Journal
- Accession number :
- 31917721
- Full Text :
- https://doi.org/10.1097/IJG.0000000000001439