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Retrospective outcome evaluation for dogs with surgically excised, solitary Kiupel high-grade, cutaneous mast cell tumours.
- Source :
-
Veterinary and comparative oncology [Vet Comp Oncol] 2020 Sep; Vol. 18 (3), pp. 402-408. Date of Electronic Publication: 2020 Jan 14. - Publication Year :
- 2020
-
Abstract
- Published outcomes for dogs with specifically high-grade mast cell tumours (MCTs), controlled for clinical stage, are few. Clinical outcomes for 49 dogs with Kiupel high-grade, clinical stage I, cutaneous MCTs were evaluated. Median survival time (MST) was 1046 days; 1 and 2-year survival rates were 79.3% and 72.9%, respectively. At study end 24 dogs had died, 23 dogs were alive (median follow-up 980 days) and 2 dogs were lost to follow-up. Death was considered MCT-related in 14 of 20 dogs with a known cause of death. Local tumour recurrence developed in nine dogs (18.4%); regional lymph node metastasis occurred in six dogs (12.2%); and a new MCT developed in 15 dogs (30.1%). Tumour location, histologic margin size and use of chemotherapy did not affect MST; increasing mitotic count (P = .001) and increasing tumour diameter (P = .024) were independently negatively prognostic. Six dogs that developed lymph node metastasis after surgery had worse MST (451 days) than 42 dogs that did not develop metastasis (1645 days); (P < .001). Our study suggests that dogs with local surgical control of clinical stage I histologically high Kiupel grade cutaneous MCT may have a long survival time; especially those with smaller tumours and a lower mitotic count. Our results suggest that evaluation of staging information and mitotic count may be equally helpful as histologic grading when making a prognosis; and highlight the importance of not relying on histologic grade alone when predicting survival for dogs with MCT.<br /> (© 2020 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Dog Diseases surgery
Dogs
Mastocytosis, Cutaneous pathology
Mastocytosis, Cutaneous surgery
Neoplasm Staging methods
Prognosis
Retrospective Studies
Skin Neoplasms pathology
Skin Neoplasms surgery
Survival
Dog Diseases pathology
Mastocytosis, Cutaneous veterinary
Neoplasm Staging veterinary
Skin Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5829
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary and comparative oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31916687
- Full Text :
- https://doi.org/10.1111/vco.12565