Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model.

Authors :: Wong SSW
Krylov VB
Argunov DA
Karelin AA
Bouchara JP
Fontaine T
Latgé JP
Nifantiev NE
Source :: MSphere [mSphere] 2020 Jan 08; Vol. 5 (1). Date of Electronic Publication: 2020 Jan 08.
Publication Year :: 2020
Abstract: Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.<br /> (Copyright © 2020 Wong et al.)

Subjects :: Antigens, Fungal chemistry
Aspergillosis microbiology
Epitopes chemistry
Epitopes immunology
Galactose analogs & derivatives
Humans
Immunomodulation
Antigens, Fungal immunology
Aspergillus fumigatus chemistry
Cell Wall immunology
Mannans immunology
Oligosaccharides chemical synthesis
Oligosaccharides immunology

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