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Cefoperazone-sulbactam and risk of coagulation disorders or bleeding: a retrospective cohort study.
- Source :
-
Expert opinion on drug safety [Expert Opin Drug Saf] 2020 Mar; Vol. 19 (3), pp. 339-347. Date of Electronic Publication: 2020 Jan 27. - Publication Year :
- 2020
-
Abstract
- Objectives : Limited evidence has suggested that cefoperazone-sulbactam causes coagulation disorders and bleeding. Methods : The authors conducted a retrospective study to compare patients receiving cefoperazone-sulbactam versus those treated with cefoperazone-tazobactam or ceftazidime. Propensity-score matching was used to explore whether treatment with cefoperazone-sulbactam increased the risk of prothrombin time (PT) prolongation, coagulation disorders, and bleeding, or decreased platelets (PLT). Results : The cohort included 23,242 patients. Among patients receiving cefoperazone-sulbactam, the risk of PT prolongation, coagulation disorders, decreased PLT, and bleeding was 5.3%, 9.2%, 15.7%, and 4.2%, respectively. Propensity-score matching analyses suggested that cefoperazone-sulbactam increased the risk of PT prolongation (aOR 2.26, 95% CI 1.61-3.18), coagulation disorders (aOR 1.81, 95% CI 1.43-2.30), and decreased PLT (aOR 1.46, 95% CI 1.25-1.72), but not increase bleeding (aOR 1.05, 95% CI 0.79-1.40) compared with ceftazidime. Patients receiving cefoperazone-sulbactam had higher risk of PT prolongation (aOR 1.53, 95% CI 1.11-2.10), coagulation disorders (aOR 1.53, 95% CI 1.21-1.95), but not decreased PLT (aOR 0.93, 95% CI 0.81-1.07) or bleeding (aOR 1.11, 95% CI 0.87-1.42), compared with those receiving cefoperazone-tazobactam. Conclusion : Cefoperazone-sulbactam may be associated with a higher risk of PT prolongation and coagulation disorders compared with cefoperazone-tazobactam and ceftazidime.
- Subjects :
- Adolescent
Adult
Aged
Anti-Bacterial Agents adverse effects
Blood Platelets drug effects
Ceftazidime adverse effects
Drug Therapy, Combination adverse effects
Female
Humans
Male
Middle Aged
Prothrombin Time statistics & numerical data
Tazobactam adverse effects
Young Adult
Blood Coagulation Disorders chemically induced
Cefoperazone adverse effects
Hemorrhage chemically induced
Sulbactam adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1744-764X
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Expert opinion on drug safety
- Publication Type :
- Academic Journal
- Accession number :
- 31914329
- Full Text :
- https://doi.org/10.1080/14740338.2020.1713090