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Systemic Oxidative Stress Is Increased in Postmenopausal Women and Independently Associates with Homocysteine Levels.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 02; Vol. 21 (1). Date of Electronic Publication: 2020 Jan 02. - Publication Year :
- 2020
-
Abstract
- Oxidative stress plays a pivotal role in the pathogenesis of cardiovascular diseases (CVD). Postmenopausal women have an increased risk of developing CVD due to decreased estrogen availability, which is accompanied by increased oxidative stress. Serum free thiols (R-SH) provide a robust and powerful read-out of systemic oxidative stress. In this study, we aimed to establish serum levels of free thiols and explore associations between free thiols and demographic, clinical, and biochemical parameters related to obesity and the risk for developing CVD in both pre- and postmenopausal women. Serum free thiols were measured in a cohort consisting of healthy pre- ( n = 223) and postmenopausal ( n = 118) Omani women. Postmenopausal women had significantly lower levels of serum free thiols as compared to premenopausal women (762.9 ± 85.3 vs. 780 ± 80.9 μM, age-adjusted p < 0.001). Women's age was positively associated with serum free thiol levels in premenopausal women (β = 0.36, p = 0.002), whereas an inverse association was observed in postmenopausal women (β = -0.29, p = 0.002). Homocysteine levels were significantly inversely associated with serum free thiol levels in both pre- (β = -0.19, p = 0.005) and postmenopausal (β = -0.20, p = 0.032) women, independent from known cardiovascular risk factors. In this study, we show that postmenopausal women are affected by increased systemic oxidative stress, which independently associates with homocysteine levels.
- Subjects :
- Adult
Cardiovascular Diseases metabolism
Cohort Studies
Cross-Sectional Studies
Female
Homocysteine metabolism
Humans
Middle Aged
Obesity blood
Obesity metabolism
Oman
Postmenopause metabolism
Premenopause blood
Risk Factors
Sulfhydryl Compounds metabolism
Cardiovascular Diseases blood
Homocysteine blood
Oxidative Stress physiology
Postmenopause blood
Sulfhydryl Compounds blood
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31906485
- Full Text :
- https://doi.org/10.3390/ijms21010314