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Efficacy of miltefosine therapy against subcutaneous experimental pythiosis in rabbits.
- Source :
-
Journal de mycologie medicale [J Mycol Med] 2020 Apr; Vol. 30 (1), pp. 100919. Date of Electronic Publication: 2019 Dec 16. - Publication Year :
- 2020
-
Abstract
- We evaluated the in vitro activity of miltefosine against 29 Pythium spp. and the in vivo therapeutic response of 2mg/kg/day of miltefosine given orally to rabbit with pythiosis induced experimentally. The MICs (in μg/mL) of miltefosine was medium-dependent and ranged from 0.5 to 2 and 32-64 on RPMI 1640 and Mueller Hinton broth, respectively. The treatment with miltefosine demonstrated significantly lower subcutaneous lesion areas compared to the control group but was not sufficient for the complete remission of the lesions. This study indicates that miltefosine has limited efficacy against pythiosis and furthers in vitro and in vivo studies are necessary to determine the possible potential of this drug in the treatment of pythiosis.<br /> (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Animals
Dermatomycoses microbiology
Dermatomycoses pathology
Disease Models, Animal
Disease Progression
Dose-Response Relationship, Drug
Female
Humans
Microbial Sensitivity Tests
Phosphorylcholine therapeutic use
Pythiosis microbiology
Pythiosis pathology
Pythium isolation & purification
Pythium pathogenicity
Rabbits
Subcutaneous Tissue microbiology
Treatment Outcome
Antifungal Agents therapeutic use
Dermatomycoses drug therapy
Phosphorylcholine analogs & derivatives
Pythiosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1773-0449
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal de mycologie medicale
- Publication Type :
- Academic Journal
- Accession number :
- 31901425
- Full Text :
- https://doi.org/10.1016/j.mycmed.2019.100919