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The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis.
- Source :
-
European journal of clinical nutrition [Eur J Clin Nutr] 2020 Jun; Vol. 74 (6), pp. 891-899. Date of Electronic Publication: 2020 Jan 03. - Publication Year :
- 2020
-
Abstract
- Background/objectives: Ulcerative colitis (UC) is an immune-mediated disease that causes inflammation in the gastrointestinal tract. Diet has an important role in the treatment of UC. This study aimed to compare the effects of extra virgin olive oil (EVOO), as a functional food, with canola oil in the treatment of UC.<br />Subjects/methods: Forty patients were participating in this crossover clinical trial. Thirty two patients completed two intervention rounds. Blood samples were taken before and after 20 days intervention. Disease activity score and gastrointestinal symptoms were evaluated using the Mayo score and gastrointestinal symptom rating scale (GSRS) respectively.<br />Results: Erythrocyte sedimentation rate (p = 0.03) and high-sensitivity C-reactive protein (p < 0.001) were decreased significantly after EVOO consumption. Bloating, constipation, fecal urgency, incomplete defecation, and final GSRS were reduced significantly after EVOO consumption (p < 0.05).<br />Conclusions: Intake of EVOO decreased the inflammatory markers and improved gastrointestinal symptoms in UC patients. It seems this functional food can be beneficial in the treatment of UC as a complementary medicine.
- Subjects :
- Adult
Biomarkers blood
Colitis, Ulcerative blood
Colitis, Ulcerative pathology
Complementary Therapies
Cross-Over Studies
Female
Humans
Male
Colitis, Ulcerative diet therapy
Colitis, Ulcerative physiopathology
Functional Food
Olive Oil pharmacology
Olive Oil therapeutic use
Rapeseed Oil pharmacology
Rapeseed Oil therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5640
- Volume :
- 74
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 31901082
- Full Text :
- https://doi.org/10.1038/s41430-019-0549-z