Back to Search
Start Over
Physicochemical properties of polysaccharide fractions from Sargassum fusiforme and their hypoglycemic and hypolipidemic activities in type 2 diabetic rats.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2020 Mar 15; Vol. 147, pp. 428-438. Date of Electronic Publication: 2019 Dec 30. - Publication Year :
- 2020
-
Abstract
- Two polysaccharide fractions (SFPs, designated as respectively SFP-1 and SFP-2) were acquired from Sargassum fusiforme by ultrasound-assisted enzymatic extraction, and their physicochemical properties and hypoglycemic and hypolipidemic effects were investigated. Structural analysis indicated that SFPs were obvious different in the zeta potential, molecular weight distribution, characteristic organic group, microstructure and the contents of total sugar, uronic acid, sulfate and moisture. SFPs consisted of fucose, mannose, rhamnose, glucose, galactose and glucuronic acid with different molar ratios. Congo red test explained that SFPs had no triple-helix structure. SFP-1 exhibited lower viscosity due to its lower molecular weight. Regarding to hypoglycemic and hypolipidemic effects, oral administration of SFPs prominently restrained loss of body weight and increase of water intake, and also significantly controlled the increase of levels of fasting blood glucose, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), uric acid (UA), urea nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of diabetic rats, and SFP-2 showed better effects in controlling fasting blood glucose, ALT, UA and BUN levels. Intervention of SFP-2 reduced the levels of insulin, FFA and TBA of diabetic rats. Histomorphological observation further demonstrated that SFPs could attenuate liver and kidney damage caused by hyperglycemia and hyperlipidemia. Data indicated that SFPs, especially SFP-2, significantly improved hyperglycemia, hyperlipidemia and liver and kidney function of diabetic rats.<br />Competing Interests: Declaration of competing interest On behalf of all authors, the corresponding author states that there is no conflict of interest.<br /> (Copyright © 2019. Published by Elsevier B.V.)
- Subjects :
- Animals
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Experimental pathology
Diabetes Mellitus, Type 2 metabolism
Diabetes Mellitus, Type 2 pathology
Male
Rats
Rats, Sprague-Dawley
Diabetes Mellitus, Experimental drug therapy
Diabetes Mellitus, Type 2 drug therapy
Hypoglycemic Agents chemistry
Hypoglycemic Agents pharmacology
Hypolipidemic Agents chemistry
Hypolipidemic Agents pharmacology
Polysaccharides chemistry
Polysaccharides pharmacology
Sargassum chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 147
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 31899245
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2019.12.243