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Advances in Gut Microbiota of Viral Hepatitis Cirrhosis.

Authors :
Wang Y
Pan CQ
Xing H
Source :
BioMed research international [Biomed Res Int] 2019 Nov 22; Vol. 2019, pp. 9726786. Date of Electronic Publication: 2019 Nov 22 (Print Publication: 2019).
Publication Year :
2019

Abstract

Although gut dysbiosis appears in 20%-75% of cirrhotic patients, there are limited data on microbiota profiles in viral hepatitis cirrhotics and its role in progression to cirrhosis. Further understanding on the relationship between gut dysbiosis and cirrhosis presents a unique opportunity in not only predicting the development of cirrhosis but also discovering new therapies. Recent advances have been made on identifying unique microbiota in viral hepatitis cirrhotics and adopting the microbiota index to predict cirrhosis. Therapeutic intervention with microbiome-modulating has been explored. Cirrhosis from viral infection has unique bacterial or fungal profiles, which include increased numbers of Prevotella , Streptococcus , Staphylococcaceae, and Enterococcus , as well as decreased Ruminococcus and Clostridium . In addition, the gut microbiota can stimulate liver immunity, effectively helping hepatitis virus clearance. In clinical settings, CDR, GDI, Basidiomycota / Ascomycota , specific POD, and so forth are efficient microbiota indexes to diagnose or prognosticate cirrhosis from viral hepatitis. FMT, probiotics, and prebiotics can restore microbial diversity in cirrhotic patients with viral hepatitis, decrease ammonia serum or endotoxemia levels, prevent complications, reduce rehospitalization rate, and improve prognosis. Cirrhotics from viral hepatitis had unique bacterial or fungal profiles, associated with specific metabolic, immune, and endocrinological statuses. Such profiles are modifiable with medical treatment. The role of gut archaea and virome, implementation of FMT, microbiota metabolites as adjuvant immunotherapy, and microbiota indexes for prognostication deserve attention.<br />Competing Interests: The authors have no conflicts of interest to declare.<br /> (Copyright © 2019 Yixuan Wang et al.)

Details

Language :
English
ISSN :
2314-6141
Volume :
2019
Database :
MEDLINE
Journal :
BioMed research international
Publication Type :
Academic Journal
Accession number :
31886272
Full Text :
https://doi.org/10.1155/2019/9726786