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A randomized, double-blind, placebo-controlled trial investigating the effect of ticagrelor on saphenous vein graft patency in patients undergoing coronary artery bypass grafting surgery-Rationale and design of the POPular CABG trial.
- Source :
-
American heart journal [Am Heart J] 2020 Feb; Vol. 220, pp. 237-245. Date of Electronic Publication: 2019 Dec 13. - Publication Year :
- 2020
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Abstract
- Rationale: An estimated 15% of saphenous vein grafts (SVGs) occlude in the first year after coronary artery bypass grafting (CABG) despite aspirin therapy. Graft occlusion can result in symptoms, myocardial infarction, and death. SVG occlusion is primarily caused by atherothrombosis, in which platelet activation plays a pivotal role. Evidence regarding the effect of stronger platelet inhibition on SVG patency after CABG is limited. The main objective of the POPular CABG trial is to determine whether dual antiplatelet therapy with aspirin plus ticagrelor improves SVG patency when compared to aspirin alone.<br />Study: The POPular CABG is a randomized, double-blind, placebo-controlled, multicenter trial investigating the effect of adding ticagrelor to standard aspirin therapy on the rate of SVG occlusion. A total of 500 patients undergoing CABG with ≥ 1 SVG are randomized to ticagrelor or placebo. The primary end point is SVG occlusion rate, assessed with coronary computed tomography angiography at 1 year. Secondary end points are stenoses and occlusions in both SVGs and arterial grafts and SVG failure at 1 year, defined as a composite of SVG occlusion on coronary computed tomography angiography or coronary angiography, SVG revascularization, myocardial infarction in the territory supplied by an SVG, or sudden death. Safety end points are bleeding events at 30 days and 1 year.<br />Conclusion: The POPular CABG trial investigates whether adding ticagrelor to standard aspirin after CABG reduces the rate of SVG occlusion at 1 year.<br /> (Copyright © 2019. Published by Elsevier Inc.)
- Subjects :
- Aged
Computed Tomography Angiography
Coronary Angiography methods
Death, Sudden, Cardiac etiology
Double-Blind Method
Drug Therapy, Combination
Graft Occlusion, Vascular diagnostic imaging
Graft Occlusion, Vascular epidemiology
Humans
Myocardial Infarction etiology
Placebos pharmacology
Research Design
Sample Size
Vascular Patency drug effects
Aspirin therapeutic use
Coronary Artery Bypass
Graft Occlusion, Vascular drug therapy
Platelet Aggregation Inhibitors pharmacology
Saphenous Vein transplantation
Ticagrelor pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6744
- Volume :
- 220
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 31884246
- Full Text :
- https://doi.org/10.1016/j.ahj.2019.12.001