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Cross-Reactivity with Self-Antigen Tunes the Functional Potential of Naive B Cells Specific for Foreign Antigens.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Feb 01; Vol. 204 (3), pp. 498-509. Date of Electronic Publication: 2019 Dec 27. - Publication Year :
- 2020
-
Abstract
- Upon Ag exposure, naive B cells expressing BCR able to bind Ag can undergo robust proliferation and differentiation that can result in the production of Ab-secreting and memory B cells. The factors determining whether an individual naive B cell will proliferate following Ag encounter remains unclear. In this study, we found that polyclonal naive murine B cell populations specific for a variety of foreign Ags express high levels of the orphan nuclear receptor Nur77, which is known to be upregulated downstream of BCR signaling as a result of cross-reactivity with self-antigens in vivo. Similarly, a fraction of naive human B cells specific for clinically-relevant Ags derived from respiratory syncytial virus and HIV-1 also exhibited an IgM <superscript>LOW</superscript> IgD <superscript>+</superscript> phenotype, which is associated with self-antigen cross-reactivity. Functionally, naive B cells expressing moderate levels of Nur77 are most likely to proliferate in vivo following Ag injection. Together, our data indicate that BCR cross-reactivity with self-antigen is a common feature of populations of naive B cells specific for foreign Ags and a moderate level of cross-reactivity primes individual cells for optimal proliferative responses following Ag exposure.<br /> (Copyright © 2020 by The American Association of Immunologists, Inc.)
- Subjects :
- Animals
Antibody Formation
Cell Differentiation
Cells, Cultured
Immunologic Memory
Lymphocyte Activation
Lymphocyte Count
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Antigen, B-Cell genetics
Autoantigens immunology
B-Lymphocyte Subsets immunology
B-Lymphocytes immunology
Cross Reactions immunology
Receptors, Antigen, B-Cell metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 204
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 31882518
- Full Text :
- https://doi.org/10.4049/jimmunol.1900799