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Evaluation of Intraarterial Thrombolysis in Treatment of Cosmetic Facial Filler-Related Ophthalmic Artery Occlusion.
- Source :
-
Plastic and reconstructive surgery [Plast Reconstr Surg] 2020 Jan; Vol. 145 (1), pp. 42e-50e. - Publication Year :
- 2020
-
Abstract
- Background: With an increase in recent years in the number of people receiving cosmetic facial injection treatments of hyaluronic acid, the incidence of hyaluronic acid embolism has also increased commensurately. Hyaluronic acid embolism leads to serious complications, including blindness, eye and eyelid movement disorders, skin necrosis, and cerebral embolism. However, there is a lack of robust clinical evidence regarding the benefits of treatment for hyaluronic acid embolism by intraarterial thrombolysis therapy.<br />Methods: This study included 24 patients with a decrease in visual acuity and other complications induced by facial hyaluronic acid injection. Patients underwent emergency intraarterial thrombolysis therapy by injection of hyaluronidase (500 to 1500 units) alone or hyaluronidase (750 to 1500 units) combined with urokinase (100,000 to 250,000 units), followed in both cases by a general symptomatic treatment and nutritional therapy.<br />Results: Ten (42 percent) of 24 patients ultimately had improvements to visual acuity, even when the clinical application of the thrombolytic treatments had passed the recommended window for optimal treatment. In all cases, patients' facial skin necrosis was restored to nearly normal appearance. In addition, the authors found that hyaluronidase combined with urokinase was a more effective therapy than hyaluronidase alone.<br />Conclusions: The authors' results indicate that intraarterial thrombolysis therapy is beneficial to patients suffering from blindness induced by hyaluronic acid embolism. The therapy was shown to be worthy of clinical application because it alleviated the impairment to patients' vision and was also beneficial in the recovery from other serious complications, including eye movement disorder, eye edema, headaches, and skin necrosis.<br />Clinical Question/level of Evidence: Therapeutic, IV.
- Subjects :
- Adult
Angiography, Digital Subtraction
Blindness etiology
Dermal Fillers administration & dosage
Drug Therapy, Combination methods
Embolism diagnostic imaging
Embolism etiology
Embolism pathology
Eye blood supply
Female
Follow-Up Studies
Humans
Hyaluronic Acid administration & dosage
Hyaluronic Acid adverse effects
Hyaluronoglucosaminidase therapeutic use
Injections, Intra-Arterial
Injections, Subcutaneous adverse effects
Male
Ophthalmic Artery diagnostic imaging
Retrospective Studies
Treatment Outcome
Urokinase-Type Plasminogen Activator therapeutic use
Visual Acuity
Blindness drug therapy
Cosmetic Techniques adverse effects
Dermal Fillers adverse effects
Embolism drug therapy
Ophthalmic Artery pathology
Thrombolytic Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1529-4242
- Volume :
- 145
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Plastic and reconstructive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 31881603
- Full Text :
- https://doi.org/10.1097/PRS.0000000000006313