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Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge.
- Source :
-
Oral diseases [Oral Dis] 2020 Apr; Vol. 26 (3), pp. 656-669. Date of Electronic Publication: 2020 Jan 22. - Publication Year :
- 2020
-
Abstract
- Objective: Burning mouth syndrome (BMS) is a chronic oral pain condition with unknown aetiology but assumed to involve peripheral/central neuropathological and immune-mediated inflammatory factors. We aimed at characterizing inflammatory and neurogenic profiles and oral symptomatology of patients with BMS based on response to a local anaesthetic lozenge.<br />Methods: Patients with BMS were divided into an Effect (n = 13), No effect (n = 8) or Unspecified (n = 2) group according to their response to a local anaesthetic lozenge on oral pain. Inflammation was assessed in blood plasma and saliva by analyses of IL-6, IL-8, IL-17A, IL-23 and TNF-α levels. The degree of inflammation and distribution of oestrogen receptor, NGF, NGF-receptor, TRPV-1 and IL-17F in buccal mucosal tissue were investigated by immunohistochemistry.<br />Results: Immunoreactivity to the oestrogen receptor was most intense in the Effect group, whereas the No effect group tended to have higher plasma levels of the pro-inflammatory cytokines.<br />Conclusions: Our findings indicate that the response to treatment with local anaesthesia enables subgrouping of patients with BMS according to the potential pathogenic mechanisms. Effect of local anaesthesia indicates a peripheral neuropathology involving lack of oestrogen and upregulation of oestrogen receptors, and no effect indicates a systemic inflammation-induced mechanism leading to increased levels of plasma cytokines.<br /> (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1601-0825
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oral diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31880064
- Full Text :
- https://doi.org/10.1111/odi.13267