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A hirudin catching ELISA for quantitating the anticoagulant in biological fluids.
- Source :
-
Thrombosis research [Thromb Res] 1988 Sep 15; Vol. 51 (6), pp. 617-25. - Publication Year :
- 1988
-
Abstract
- A catching ELISA has been developed that permits a quantitation of the anticoagulant hirudin in buffer, urine and plasma. In plasma hirudin can be determined in concentrations ranging from 0.2 to 25 ng/ml (2.4 X 10(-3) to 0.3 AT-U/ml), in urine between 0.8 and 200 ng/ml (0.01 and 2.4 AT-U/ml). The enzyme immunoassay allows a rapid, sensitive and reproducible quantitation of hirudin, and can thus be used to assess the pharmacokinetics of the anticoagulant in patients after parenteral and/or topic administration.
Details
- Language :
- English
- ISSN :
- 0049-3848
- Volume :
- 51
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 3187968
- Full Text :
- https://doi.org/10.1016/0049-3848(88)90145-4