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Computerized Analysis of Brain MRI Parameter Dynamics in Young Patients With Cushing Syndrome-A Case-Control Study.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 May 01; Vol. 105 (5). - Publication Year :
- 2020
-
Abstract
- Background: Young patients with Cushing Syndrome (CS) may develop cognitive and behavioral alterations during disease course.<br />Methods: To investigate the effects of CS on the brain, we analyzed consecutive MRI scans of patients with (n = 29) versus without CS (n = 8). Multiple brain compartments were processed for total and gray/white matter (GM/WM) volumes and intensities, and cortical volume, thickness, and surface area. Dynamics (last/baseline scans ratio per parameter) were analyzed versus cortisol levels and CS status (persistent, resolved, and non-CS).<br />Results: Twenty-four-hour urinary free cortisol (24hUFC) measurements had inverse correlation with the intensity of subcortical GM structures and of the corpus callosum, and with the cerebral WM intensity. 24hUFC dynamics had negative correlation with volume dynamics of multiple cerebral and cerebellar structures. Patients with persistent CS had less of an increase in cortical thickness and WM intensity, and less of a decrease in WM volume compared with patients with resolution of CS. Patients with resolution of their CS had less of an increase in subcortical GM and cerebral WM volumes, but a greater increase in cortical thickness of frontal lobe versus controls.<br />Conclusion: Changes in WM/GM consistency, intensity, and homogeneity in patients with CS may correlate with CS clinical consequences better than volume dynamics alone.<br /> (Published by Oxford University Press on behalf of the Endocrine Society 2019.)
- Subjects :
- Adolescent
Adult
Brain growth & development
Brain pathology
Case-Control Studies
Child
Child Development
Child, Preschool
Cushing Syndrome pathology
Cushing Syndrome psychology
Cushing Syndrome urine
Female
Gray Matter diagnostic imaging
Gray Matter growth & development
Gray Matter pathology
Humans
Hydrocortisone urine
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Neuroimaging
Organ Size
Retrospective Studies
White Matter diagnostic imaging
White Matter growth & development
White Matter pathology
Young Adult
Brain diagnostic imaging
Cushing Syndrome diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 105
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 31875913
- Full Text :
- https://doi.org/10.1210/clinem/dgz303